Spokesman for the family, Jim McGrath, announced Barbara’s death on Tuesday evening at the age of 92, after a series of recent hospitalisation.
U.S President Donald Trump ordered flags be flown at half mast in her honour. The president recalled Bush for her commitment to spreading literacy, and as an “advocate of the American family.”
In a statement, he noted that she will be long remembered for her strong devotion to country and family, both of which she served unfailingly well.
Politicians across the aisles also mourned the death of Barbara, recalling the former first lady for her dedication to her country and family.
Barbara was the second woman to ever have her husband and son both serve as president.
She served as first lady during the presidency of her husband, George H.W. Bush while her oldest son was elected president in 2000 and served two terms.
Her younger son, Jeb Bush, served two terms as governor of Florida, and ran an unsuccessful presidential campaign for the Republican nomination in 2016.
U.S. President Donald Trump and First Lady Melania, former Presidents and first ladies Barack Obama and Michelle, and Bill Clinton and Hillary were among dignitaries that have mourned former First Lady Barbara Bush.